Cognitive
Semax
10mg
$99
Russian-developed ACTH analog that upregulates BDNF, enhances dopaminergic and serotonergic tone, and improves memory, focus, and neuroprotection.
- Tested by Freedom Diagnostics — independent US lab
- COA published with every lot
- Shipped from the US
For in-vitro research use only. Not for human or veterinary consumption, diagnostic, or therapeutic use.
Semax is a heptapeptide analog of ACTH(4-10) developed at the Institute of Molecular Genetics in Moscow and approved in Russia for stroke, cognitive decline, and optic nerve disease. It dramatically upregulates BDNF (brain-derived neurotrophic factor) and its receptor TrkB, enhancing synaptic plasticity and neuronal survival. It also modulates dopaminergic, serotonergic, and cholinergic systems for acute cognitive enhancement.
Semax binds melanocortin receptors (MC4R) and activates BDNF/TrkB signaling, stimulating synaptic potentiation and neurogenesis in the hippocampus. It increases enkephalins and modulates the dopamine/serotonin balance in prefrontal cortex. It also exhibits anti-inflammatory neuroprotective effects by reducing pro-inflammatory cytokine expression following ischemic injury.
- Molecular Formula
- C₃₇H₅₁N₉O₁₀S
- Molecular Weight
- 813.9 g/mol
- Form
- Lyophilized peptide powder
- Solubility
- Soluble in sterile water or saline
- Dosage Range
- 200–900mcg daily intranasal (research context)
- Plasma Half-Life
- ~20 minutes (plasma); prolonged CNS effects
- Bioavailability
- ~90% intranasal
Certificate of analysis
Independent third-party report for the lot you receive — identity and purity. Available on request with your order; we'll email it back the same business day.
Cold-chain when required
Temperature-sensitive peptides ship with insulation and coolant. Store as indicated on the vial. Stability notes included with the order.
For research only
Sold for in-vitro research and laboratory use. Not for human or veterinary consumption. We don't advise on protocols or dosing.
- [01]
Semax and BDNF upregulation in rat brain
Shadrina M.I. et al. · Journal of Molecular Neuroscience · 2010
Semax administration produced a 1.6-fold increase in BDNF mRNA expression in the rat hippocampus within 24 hours.
- [02]
Neuroprotective effects of Semax in ischemic stroke
Miasoedov N.F. et al. · Zhurnal Nevrologii i Psikhiatrii · 1999
Semax reduced infarct volume and improved neurological outcomes in a randomized controlled trial of acute ischemic stroke patients.
- [03]
ACTH(4-10) analogs and cognitive performance
De Wied D. · Progress in Brain Research · 1990
ACTH fragment analogs improved attention, memory consolidation, and cognitive flexibility in both animal models and human trials.
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