Recovery & Repair
TB-500
5mg
$89
Synthetic fragment of Thymosin Beta-4 that promotes tissue repair, reduces inflammation, and accelerates healing of muscle, tendon, and ligament injuries.
- Tested by Freedom Diagnostics — independent US lab
- COA published with every lot
- Shipped from the US
For in-vitro research use only. Not for human or veterinary consumption, diagnostic, or therapeutic use.
TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4, found in high concentrations at injury sites. It promotes actin regulation, cellular migration, and angiogenesis to accelerate tissue repair. TB-500 has been studied in equine and rodent models for its ability to heal tendons, heart tissue, skin wounds, and corneal injuries.
TB-500 sequesters G-actin monomers via its LKKTET actin-binding domain, regulating actin polymerization dynamics critical for cell migration and wound healing. It upregulates metalloproteinase MMP-2, promotes endothelial cell differentiation, and stimulates VEGF-mediated angiogenesis. Its anti-inflammatory effects are mediated via NF-κB pathway downregulation.
- Molecular Formula
- C₂₁₂H₃₅₀N₅₆O₇₈S
- Molecular Weight
- ~4.9 kDa
- Form
- Lyophilized peptide powder
- Solubility
- Soluble in bacteriostatic water
- Dosage Range
- 2–5mg twice weekly (research context)
- Plasma Half-Life
- ~5–6 hours
- Bioavailability
- ~85% subcutaneous
Certificate of analysis
Independent third-party report for the lot you receive — identity and purity. Available on request with your order; we'll email it back the same business day.
Cold-chain when required
Temperature-sensitive peptides ship with insulation and coolant. Store as indicated on the vial. Stability notes included with the order.
For research only
Sold for in-vitro research and laboratory use. Not for human or veterinary consumption. We don't advise on protocols or dosing.
- [01]
Thymosin beta-4 and cardiac repair
Bock-Marquette I. et al. · Nature · 2004
Thymosin Beta-4 activated cardiac progenitor cells and significantly improved cardiac function after myocardial infarction in mouse models.
- [02]
Thymosin beta-4 promotes corneal wound healing
Sosne G. et al. · Experimental Eye Research · 2001
TB-4 accelerated corneal epithelial wound closure and reduced inflammatory infiltrate in multiple animal models.
- [03]
Anti-inflammatory mechanism of thymosin beta-4
Sosne G. et al. · Annals of the New York Academy of Sciences · 2007
TB-4 suppressed NF-κB signaling and reduced pro-inflammatory cytokine expression in corneal and systemic inflammatory models.
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