Longevity

Epithalon

Longevity

10mg

$109

Tetrapeptide developed by the St. Petersburg Institute of Bioregulation that activates telomerase, lengthens telomeres, and regulates the pineal gland for anti-aging effects.

Tested by Freedom Diagnostics — independent US lab
COA published with every lot
Shipped from the US

For in-vitro research use only. Not for human or veterinary consumption, diagnostic, or therapeutic use.

Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. It activates telomerase in somatic cells, elongating telomeres and potentially extending cellular lifespan. Human trials spanning 12+ years have reported improvements in melatonin secretion, immune function, and reduced mortality in elderly cohorts.

Epithalon stimulates telomerase (hTERT) expression in somatic cells, counteracting the telomere shortening that occurs with each cell division. It also regulates pineal gland function, restoring melatonin secretion that declines with age. Additional mechanisms include upregulation of antioxidant enzymes (superoxide dismutase, catalase) and modulation of cortisol/melatonin ratios.

Molecular Formula: C₁₄H₂₂N₄O₉
Molecular Weight: 390.3 g/mol
Form: Lyophilized tetrapeptide powder
Solubility: Freely soluble in water
Dosage Range: 5–10mg daily for 10–20 day cycles (research context)
Plasma Half-Life: ~2 hours
Bioavailability: ~80% subcutaneous

Certificate of analysis
Independent third-party report for the lot you receive — identity and purity. Available on request with your order; we'll email it back the same business day.
Cold-chain when required
Temperature-sensitive peptides ship with insulation and coolant. Store as indicated on the vial. Stability notes included with the order.
For research only
Sold for in-vitro research and laboratory use. Not for human or veterinary consumption. We don't advise on protocols or dosing.

[01]
Peptide regulation of aging
Khavinson V.K. · Neuroendocrinology Letters · 2002
Epithalon restored melatonin secretion and improved antioxidant status in elderly patients over a 12-year follow-up study.
[02]
Epithalon activates telomerase and elongates telomeres in human cells
Khavinson V. et al. · Bulletin of Experimental Biology and Medicine · 2003
Epithalon induced telomerase activity in human somatic cells and produced measurable telomere elongation after treatment.
[03]
Effect of Epithalon on mortality of elderly cohort
Anisimov V.N. et al. · Gerontology · 2003
Epithalon treatment in elderly subjects was associated with a statistically significant reduction in all-cause mortality over a 6-year observation period.

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