Longevity
SS-31
10mg
$63
Szeto-Schiller peptide that targets the inner mitochondrial membrane to reduce oxidative stress, restore mitochondrial function, and support cellular energy production.
- Tested by Freedom Diagnostics — independent US lab
- COA published with every lot
- Shipped from the US
For in-vitro research use only. Not for human or veterinary consumption, diagnostic, or therapeutic use.
SS-31 (elamipretide) is a cell-permeable tetrapeptide that selectively concentrates in the inner mitochondrial membrane with 1,000-fold higher uptake than the cytoplasm. It binds to cardiolipin, a phospholipid critical for cristae structure and electron transport chain efficiency. Clinical trials have demonstrated improvements in heart failure, age-related muscle decline, and mitochondrial disease.
SS-31 interacts with cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure and maintaining optimal cytochrome c association for electron transport. This reduces electron leak and superoxide generation, lowers mitochondrial ROS, and restores ATP synthesis efficiency. It also inhibits cardiolipin peroxidation, preventing pro-apoptotic cytochrome c release.
- Molecular Formula
- C₃₂H₄₈N₈O₆
- Molecular Weight
- 736.8 g/mol
- Form
- Lyophilized tetrapeptide powder
- Solubility
- Freely soluble in water
- Dosage Range
- 0.1–0.25 mg/kg daily (research context)
- Plasma Half-Life
- ~2–3 hours
- Bioavailability
- ~85% subcutaneous
Certificate of analysis
Independent third-party report for the lot you receive — identity and purity. Available on request with your order; we'll email it back the same business day.
Cold-chain when required
Temperature-sensitive peptides ship with insulation and coolant. Store as indicated on the vial. Stability notes included with the order.
For research only
Sold for in-vitro research and laboratory use. Not for human or veterinary consumption. We don't advise on protocols or dosing.
- [01]
SS-31 reverses mitochondrial dysfunction and rescues diastolic function in heart failure
Chatfield K.C. et al. · JACC: Basic to Translational Science · 2019
SS-31 restored mitochondrial cristae morphology and improved cardiac energetics in a large animal model of heart failure with preserved ejection fraction.
- [02]
Elamipretide improves mitochondrial function in aged skeletal muscle
Siegel M.P. et al. · Aging Cell · 2013
SS-31 treatment in aged mice improved mitochondrial ATP production, reduced ROS, and enhanced exercise capacity to levels approaching young animals.
- [03]
Mitochondria-targeted peptide accelerates ATP recovery and reduces ROS generation
Szeto H.H. · Pharmacology & Experimental Therapeutics · 2008
SS-31 concentrated 1,000-fold in the inner mitochondrial membrane and reduced oxidative damage by over 70% in ischemia-reperfusion injury models.
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