Longevity
MOTS-C
5mg
$48
Mitochondria-derived peptide that activates AMPK signaling to enhance metabolic flexibility, exercise performance, and insulin sensitivity.
Size
- Tested by Freedom Diagnostics — independent US lab
- COA published with every lot
- Shipped from the US
For in-vitro research use only. Not for human or veterinary consumption, diagnostic, or therapeutic use.
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino acid mitochondria-derived peptide encoded by the mitochondrial genome. It acts as a metabolic regulator that translocates to the nucleus under stress to activate AMPK and promote glucose uptake. Research shows it enhances exercise capacity, insulin sensitivity, and age-related metabolic decline.
MOTS-C activates AMPK (AMP-activated protein kinase) in skeletal muscle, stimulating glucose transporter GLUT4 expression and uptake independent of insulin. It inhibits the folate cycle and de novo purine biosynthesis, increasing AICAR levels which further activate AMPK. Under exercise stress it translocates to the nucleus to modulate gene expression linked to mitochondrial biogenesis.
- Molecular Formula
- C₇₅H₁₃₂N₂₂O₂₃S
- Molecular Weight
- 1.8 kDa
- Form
- Lyophilized peptide powder
- Solubility
- Soluble in bacteriostatic water
- Dosage Range
- 5–10mg weekly (research context)
- Plasma Half-Life
- ~2–4 hours
- Bioavailability
- ~80% subcutaneous
Certificate of analysis
Independent third-party report for the lot you receive — identity and purity. Available on request with your order; we'll email it back the same business day.
Cold-chain when required
Temperature-sensitive peptides ship with insulation and coolant. Store as indicated on the vial. Stability notes included with the order.
For research only
Sold for in-vitro research and laboratory use. Not for human or veterinary consumption. We don't advise on protocols or dosing.
- [01]
MOTS-C: a mitochondrial-derived peptide regulating muscle and fat metabolism
Lee C. et al. · Cell Metabolism · 2015
MOTS-C activated AMPK in skeletal muscle, improved insulin sensitivity, and prevented diet-induced obesity in mouse models.
- [02]
Exercise-induced mitochondrial peptide MOTS-C promotes physical performance
Reynolds J.C. et al. · Nature Communications · 2021
Exogenous MOTS-C administration enhanced running capacity and muscle function in aged mice, mimicking benefits of exercise training.
- [03]
MOTS-C and the regulation of metabolic homeostasis
Kim S.J. et al. · Experimental & Molecular Medicine · 2021
MOTS-C coordinated nuclear and mitochondrial stress responses, supporting its role as a systemic metabolic regulator.
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