Longevity
NAD+
1,000mg
$180
Nicotinamide adenine dinucleotide to replenish cellular NAD+ levels, support sirtuin activity, DNA repair, and mitochondrial energy metabolism.
- Tested by Freedom Diagnostics — independent US lab
- COA published with every lot
- Shipped from the US
For in-vitro research use only. Not for human or veterinary consumption, diagnostic, or therapeutic use.
NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme found in every cell, central to energy metabolism and over 500 enzymatic reactions. NAD+ levels decline by approximately 50% between ages 20 and 50. Replenishing NAD+ activates sirtuins (longevity-associated deacetylases), supports PARP-mediated DNA repair, and enhances mitochondrial biogenesis through PGC-1α activation.
NAD+ serves as an electron carrier in glycolysis, the TCA cycle, and oxidative phosphorylation. As a substrate for sirtuins (SIRT1–7), it regulates gene expression, inflammation, and metabolic adaptation. PARP enzymes consume NAD+ for DNA strand break repair. CD38 and SARM1 also hydrolyze NAD+, linking it to calcium signaling and neuronal stress responses.
- Molecular Formula
- C₂₁H₂₇N₇O₁₄P₂
- Molecular Weight
- 663.4 g/mol
- Form
- Lyophilized powder
- Solubility
- Freely soluble in water
- Dosage Range
- 500–1,000mg daily
- Plasma Half-Life
- ~1–2 hours (plasma NAD+)
- Bioavailability
- Variable; IV/subcutaneous preferred for systemic delivery
Certificate of analysis
Independent third-party report for the lot you receive — identity and purity. Available on request with your order; we'll email it back the same business day.
Cold-chain when required
Temperature-sensitive peptides ship with insulation and coolant. Store as indicated on the vial. Stability notes included with the order.
For research only
Sold for in-vitro research and laboratory use. Not for human or veterinary consumption. We don't advise on protocols or dosing.
- [01]
NAD+ metabolism and its roles in aging
Verdin E. · Science · 2015
NAD+ decline with age impairs sirtuin and PARP activity; supplementation restored mitochondrial function and extended lifespan in model organisms.
- [02]
Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication
Gomes A.P. et al. · Cell · 2013
Raising NAD+ in aged mice restored mitochondrial homeostasis and reversed aspects of muscle aging within one week of treatment.
- [03]
Nicotinamide adenine dinucleotide and sirtuins in aging and disease
Imai S. & Guarente L. · Trends in Cell Biology · 2014
NAD+-sirtuin signaling axis regulates metabolic adaptation, stress resistance, and genomic stability across multiple tissue types.
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